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Zinc Influx Restricts Enterovirus D68 Replication

Front Microbiol. 2021-10; 
Shunan Liu, Xia Cao, Haoran Guo, Wei Wei
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摘要

Enterovirus D68 (EV-D68) is a respiratory viral pathogen that causes severe respiratory diseases and neurologic manifestations. Since the 2014 outbreak, EV-D68 has been reported to cause severe complications worldwide. However, there are currently no approved antiviral agents or vaccines for EV-D68. In this study, we found that zinc ions exerted substantial antiviral activity against EV-D68 infection . Zinc salt treatment potently suppressed EV-D68 RNA replication, protein synthesis, and infectious virion production and inhibited cytopathic effects without producing significant cytotoxicity at virucidal concentrations (EC=0.033mM). Zinc chloride (ZnCl) treatment moderately inhibited EV-D68 attachment. Time-dose... More

关键词

EV-D68, antiviral agents, enterovirus, pyrrolidine dithiocarbamate, zinc influx