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Investigation of the mechanisms of VEGF-mediated compensatory lung growth: the role of the VEGF heparin-binding domain

Sci Rep. 2021-06; 
Lumeng J Yu, Victoria H Ko, Duy T Dao, Jordan D Secor, Amy Pan, Bennet S Cho, Paul D Mitchell, Hiroko Kishikawa, Diane R Bielenberg, Mark Puder
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Recombinant Proteins mice were randomized to three groups of daily intraperitoneal injections for four days starting on POD 0: VEGF164 (0.25 mg/kg, 0.5 mg/kg) (Z02690-1, GenScript, Piscataway, NJ) Get A Quote

摘要

Morbidity and mortality for neonates with congenital diaphragmatic hernia-associated pulmonary hypoplasia remains high. These patients may be deficient in vascular endothelial growth factor (VEGF). Our lab previously established that exogenous VEGF164 accelerates compensatory lung growth (CLG) after left pneumonectomy in a murine model. We aimed to further investigate VEGF-mediated CLG by examining the role of the heparin-binding domain (HBD). Eight-week-old, male, C57BL/6J mice underwent left pneumonectomy, followed by post-operative and daily intraperitoneal injections of equimolar VEGF164 or VEGF120, which lacks the HBD. Isovolumetric saline was used as a control. VEGF164 significantly increased lung volume,... More

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