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The Role of CD147 in Pathological Cardiac Hypertrophy Is Regulated by Glycosylation

Oxid Med Cell Longev. 2022-01; 
Fang-Yuan Zhong, Yi-Chao Zhao, Chen-Xu Zhao, Zhi-Chun Gu, Xi-Yuan Lu, Wen-Long Jiang, Ling-Chen Gao, Wen-Li Li, Zi-Han Qin, Heng Ge, Jun Pu
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Proteins, Expression, Isolation and Analysis … were extracted and quantified, a total of 1000μg protein was sub- jected to coimmunoprecipitation experiments using Anti- DYKDDDDK IP Resin (L00425; GenScript; Nanjing, China) in … Get A Quote

摘要

CD147, also known as EMMPRIN or basigin, is a transmembrane glycoprotein receptor that activates matrix metalloproteinases and promotes inflammation. CD147 function is regulated by posttranslational modifications of which glycosylation has attracted the most attention. In this study, we demonstrated that glycosylated CD147 was the dominant form in heart tissue, and its levels were markedly elevated in response to transverse aortic constriction (TAC). Adeno-associated virus 9-mediated, cardiac-specific overexpression of wild-type CD147 in mice significantly promoted pressure overload-induced pathological cardiac remodeling accompanied by augmented oxidative stress and ferroptosis. By contrast, mutations of CD147... More

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