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Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR

Vet Microbiol. 2022-01; 
Zhenyu Wang, Jing Chen, Qiong-Ge Zhang, Kai Huang, Dan Ma, Qian Du, Dewen Tong, Yong Huang
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Catalog Antibody … antibody (BM4389; Wuhan Boster Biotech), Mouse anti-β-actin antibody (A00702; GenScript Biotech Corporation), mouse … DAPI (C1005) was purchased from Beyotime Biotechnology … Get A Quote

摘要

Porcine circovirus 2 (PCV2) has been proved to increase the risk of other pathogens infection through antagonizing the host type I interferon (IFN) response. Previously, we have reported that PCV2 infection efficiently inhibits type I interferon production induced by other DNA viruses. However, whether PCV2 can inhibit type I interferon signaling is less reported. Herein, we found that PCV2 interfered with the activation of IFN signaling pathway, which led to a significantly reduced IFN-stimulated genes (ISGs) transcription after IFN-α stimulation both in vivo and in vitro. In PCV2-infected cells, IFN-induced tyrosine phosphorylation of STAT1 and STAT2 and their heterodimerization were decreased. Meanwhile, th... More

关键词

Capsid, JAK-STAT pathway, Porcine circovirus type 2 (PCV2), Type I interferon signaling, gC1qR