GenScript Protein A MagBeads are superparamagnetic beads covalently bound with recombinant protein A for antibody purification. The beads are supplied as 25% slurry in phosphate buffered saline (PBS), pH 7.4, containing 20% ethanol. The Protein A MagBeads have a binding capacity of more than 10 mg Rabbit IgG per 1 ml settled beads (e.g. 4 ml 25% slurry).
Protein A, a bacterial cell wall protein isolated from Staphylococcus aureus, binds to mammalian IgGs, mainly through Fc regions. Native Protein A has five IgG binding domains and many unknown-function repeated sequences. Recombinant Protein A only contains five high-affinity IgG binding domains to reduce nonspecific binding.

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