Cortistatin 14, human, rat
Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin 14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin 14 was injected intracerebroventricularly after footshock avoidance training into each of a group of CD-1 mice. After one week, training was resumed to
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