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SafeEdit TRAC sgRNA

SafeEdit TRAC sgRNA (HPLC)
KIOK1
询价

联系凯发一触即发
Description HPLC purified SafeEdit sgRNA with modifications targeting the first exon of the constant chain of the TCRα gene (TRAC), which enhances CAR-T cell potency and persistence by utilizing the endogenous transcriptional control of TCR gene. 

For customized sgRNA synthesis service, please visit ://www.genscript.com/crispr-cas9-single-guide-RNA-and-ribonucleoprotein.html

[Reference] Roth. et al. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature 2018, 559(7714): 405-409.
Sequence
mA*mG*mA*GUCUCUCAGCUGGUACAGUUUUAGAGCUAGAAAUAGCAAGUUAAAA
UAAGGCUAGUCCGUUAUCAACUUGAAAAAGUGGCACCGAGUCGGUGCU*mU*mU*mU
m = 2'O-Methyl RNA;  * = Phosphorothioate
Storage Condition Stable for at least 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Quality Specifications
Item Specifications
Molecular Weight ≤+/- 0.05% from theoretical molecular weight by mass spectrometry
Purity ≥90% by RNase-free HPLC

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