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Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses.

Immunology.. 2016-08; 
Patel S, Akalkotkar A, Bivona JJ 3rd, Lee JY, Park YK, Yu M, Colpitts SL, Vajdy M.
Products/Services Used Details Operation
... the final volume for each dose. All components were tested for endotoxin with a Genscript kit (Piscataway, NJ08854; Cat# L00350) and the endotoxin content in each component was found to be less than 0.005 EU/ml. All vaccines were prepared ...

摘要

Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that although mucosal and systemic vaccinations with a recombinant HIV-1BaL gp120 with either a catechin, epigallo catechin gallate (EGCG) or pro-vitamin A (retinyl palmitate) alone in a vegetable-oil-in-water emulsion (OWE) suppressed antigen-specific responses, the combination of EGCG and vitamin A or E in OWE (Nutritive Immune-enhancing Delivery System, NIDS) synergistically enhanced adaptive B-cell, and CD... More

关键词

HIV; adjuvant; flavonoid; vaccine; vegetable oil; vitamin A; vitamin E