凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Plant synthetic GP4 and GP5 proteins from porcine reproductive and respiratory syndrome virus elicit immune responses in pigs.

Planta. 2018-04; 
AnChul Han,NazkiSalik,ParkSung-Chul,JeongYu Jeong,LeeJu Huck,ParkSu-Jin,KhatunAmina,KimWon-Il,ParkYoun-Il,JeongJae Cheol,KimCha Y
Products/Services Used Details Operation
… antibody. Arrows and arrow heads indicate monomeric and dimeric forms of each protein, respectively. MT multiple tag (40 kDa) from GenScript (M0101). Glycosylation status of antigens produced in Arabidopsis leaves. The recombinant …

摘要

We demonstrated successful overexpression of porcine reproductive and respiratory syndrome virus (PRRSV)-derived GP4D and GP5D antigenic proteins in Arabidopsis. Pigs immunized with transgenic plants expressing GP4D and GP5D proteins generated both humoral and cellular immune responses to PRRSV. Porcine reproductive and respiratory syndrome virus (PRRSV) causes PRRS, the most economically significant disease affecting the swine industry worldwide. However, current commercial PRRSV vaccines (killed virus or modified live vaccines) show poor efficacy and safety due to concerns such as reversion of virus to wild type and lack of cross protection. To overcome these problems, plants are considered a promising ... More

关键词

Glycoprotein,Immunogenicity,PRRSV,Plant-based vaccine,Protein expression,Subcellular targeting ve