凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster.

Neurosci. Lett.. 2019; 
XiaoChengfeng,QiuSh
Products/Services Used Details Operation
… (2) repo-Gal4/UAS-hsp70-myc flies: primary antibody, rabbit anti-c-myc (A00173, GenScript) at 1:50 … Science Foundation of Jiangsu Province (BK20180497 to SQ), a grant for Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse of Nanjing University of …

摘要

Drosophila egg-derived tyrosine phosphatase (EDTP) is a lipid phosphatase essential for oogenesis and muscle function. Loss-of-EDTP is lethal at early developmental stages. Hypomorphic mutation of EDTP causes impaired muscle performance and shortened lifespan. Mutation of MTMR14, a mammalian homolog to EDTP, is associated with muscle fatigue in rodents and a rare genetic disease called centronuclear myopathy in humans. Despite the deleterious consequences, downregulation of MTMR14 promotes autophagy. It is proposed that selective downregulation of EDTP/MTMR14 in non-muscle tissues improves the survivorship to cellular wastes and extends lifespan. Here, we show that downregulation of EDTP in glial cells ... More

关键词

Autophagy,Drosophila melanogaster,Egg-derived tyrosine phosphatase (EDTP),Glial cell,Polyglutamine protein aggreg