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Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.

Cell Metab. 2019-04; 
WuMeng-Ju,ChenYu-Syuan,KimMi Ran,ChangChao-Ching,GampalaSilpa,ZhangYingsheng,WangYueyang,ChangChih-Yu,YangJer-Yen,ChangChu
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Monoclonal Antibody Services … Antibodies. Rabbit monoclonal anti-GST, Cell Signaling Technology, Cat#2625P; RRID: AB_10831370. Rabbit polyclonal anti-His, Genscript, Cat#A00174-40; RRID: AB_914703. Mouse monoclonal anti-Mitofusin 1, Abcam, Cat#ab57602; RRID: AB_2142624 … Get A Quote

摘要

Mitochondria are dynamic organelles that have been linked to stem cell homeostasis. However, the mechanisms involved in mitochondrial regulation of stem?cell fate determination remain elusive. Here we discover that epithelial-mesenchymal transition (EMT), a key process in cancer progression, induces mitochondrial fusion through regulation of the miR200c-PGC1α-MFN1 pathway. EMT-activated MFN1 forms a complex with PKCζ and is required for PKCζ-mediated NUMB phosphorylation and dissociation from the cortical membrane to direct asymmetric division of mammary stem cells, where fused mitochondria are tethered by MFN1-PKCζ to the cortical membrane and asymmetrically segregated to the stem cell-like progeny... More

关键词

EMT,cell plasticity,mammary stem cell,mitochondrial dynamics,mitofusin,stem cell fate,stem cell pola