凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes.

Biochim Biophys Acta Mol Cell Res. 2019-05; 
ZhangJianjian,ZhangKangning,QiLijuan,HuQiuming,ShenZhen,LiuBowen,DengJiaxin,ZhangChangsong,ZhangYan
Products/Services Used Details Operation
Recombinant Proteins GFP(GenScript, A01704, Piscataway, NJ) Get A Quote

摘要

DENN (differentially expressed in normal cells and neoplasia) domain-containing proteins are a family of guanine nucleotide exchange factors (GEFs) for Rab small GTPases and coordinate a plethora of intracellular membrane trafficking events. FAM45A is a non-classical DENN domain protein, whose function was unknown. In this study, we characterized cellular roles of FAM45A. We found that FAM45A localized mainly in late/multivesicular endosomes. Depletion of FAM45A resulted in clustering of endosomes to the perinuclear region. The endocytosis of EGF receptor was impaired in FAM45A knockdown cells due to a delay in the early-to-late endosome transition. Furthermore, the secretion of selected exosome subpopula... More

关键词

DENN domain,Endocytosis,Endosome,FAM45A,Membrane trafficking,Multivesicular endo