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Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation.

Cell Host Microbe. 2018; 
Drolia Rishi,Tenguria Shivendra,Durkes Abigail C,Turner Jerrold R,Bhunia Ar
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摘要

Intestinal epithelial cells are the first line of defense against enteric pathogens, yet bacterial pathogens, such as Listeria monocytogenes, can breach this barrier. We show that Listeria adhesion protein (LAP) induces intestinal epithelial barrier dysfunction to promote bacterial translocation. These disruptions are attributed to the production of pro-inflammatory cytokines TNF-α and IL-6, which is observed in mice challenged with WT and isogenic strains lacking the surface invasion protein Internalin A (ΔinlA), but not a lap mutant. Additionally, upon engagement of its surface receptor Hsp60, LAP activates canonical NF-κB signaling, facilitating myosin light-chain kinase (MLCK)-mediated op... More

关键词

Hsp60,InlA,LAP,Listeria monocytogenes,MLCK,NF-κB,bacterial translocation,intestinal epithelial barrier,mouse,tight junc