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Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8 T Cells in Acute Viral Infection.

J. Immunol.. 2019; 
LiuZhenyu,GuoYanyan,TangShupei,ZhouLan,HuangChunji,CaoYi,HuangHuang,WuXiaoping,MengDongwei,YeLilin,HeHaiyang,XieZhunyi,WuYuzhang,LiuXindong,ZhouXin
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Catalog Antibody Chromatin fragments were prepared as described (15), followed by immunoprecipitation with an anti-BCL6 Ab (N-3; Santa Cruz) or rabbit IgG (A01008; GenScript) coupled with the Dynabeads Protein G (10004D; Invitrogen). Get A Quote

摘要

The differentiation of memory CD8 T cells is critical to the long-term cellular immunity. The transcription factor BCL6 has been reportedly important for the generation and maintenance of memory CD8 T cells; however, using the newly established BCL6 conditional knockout mouse model, we demonstrate that BCL6 is dispensable for the maintenance of established memory CD8 T cell pool, although BCL6 is still required for the generation of CD8 memory precursors upon acute viral infection. In addition, BCL6 promotes the expression of TCF-1 via directly binding to the (gene symbol for TCF-1) allele in CD8 memory precursors and forced expression of TCF-1 restores the generation of BCL6-deficient memory precursor... More

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