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Autophagy Promotes Porcine Parvovirus Replication and Induces Non-Apoptotic Cell Death in Porcine Placental Trophoblasts.

Viruses. 2019; 
Zhang X, Xiong Y, Zhang J1, Shao T1, Chen S1, Miao B1, Wang Z1, Du Q1, Huang Y1, Tong D1.
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Monoclonal Antibody Services … Anti-β-actin (Cat No. A00702) was obtained from <b>GenScript</b> Biotech Corporation. Monoclonal<br> anti-PPV capsid protein antibody was produced by 3C9 cell clones that were obtained from<br> the American Type Culture Collection (Cat No. ATCC CRL-1745) … Get A Quote

摘要

Autophagy plays important roles in the infection and pathogenesis of many viruses, yet the regulatory roles of autophagy in the process of porcine parvovirus (PPV) infection remain unclear. Herein, we show that PPV infection induces autophagy in porcine placental trophoblasts (PTCs). Induction of autophagy by rapamycin (RAPA) inhibited the occurrence of apoptotic cell death, yet promoted viral replication in PPV-infected cells; inhibition of autophagy by 3-MA or ATG5 knockdown increased cellular apoptosis and reduced PPV replication. Interestingly, we found that in the presence of caspase-inhibitor zVAD-fmk, PPV induces non-apoptotic cell death that was characterized by lysosomal damage and associated with auto... More

关键词

autophagy; non-apoptotic cell death; parvovirus; replication