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Acute in vitro and in vivo toxicity of a commercial grade boron nitride nanotube mixture.

Nanotoxicology. 2017; 
Kodali VK, Roberts JR, Shoeb M, Wolfarth MG, Bishop L, Eye T, Barger M, Roach KA, Friend S, Schwegler-Berry D, Chen BT, Stefaniak A, Jordan KC, Whitney RR, Porter DW, Erdely AD.
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Cellular Analysis To eliminate the possibility of endo- toxin contamination as a confounder, we tested the stocks of both BNNT-M and MWCNT-7 for endotoxin contamination using a chromogenic limulus amebo- cyte lysate assay (Genscript ToxinSensorTM Chromogenic LAL Endotoxin Assay Kit, Genscript # L00351, Piscataway, NJ) as per manufacturer's instructions. Get A Quote

摘要

Boron nitride nanotubes (BNNTs) are an emerging engineered nanomaterial attracting significant attention due to superior electrical, chemical and thermal properties. Currently, the toxicity profile of this material is largely unknown. Commercial grade BNNTs are composed of a mixture (BNNT-M) of ∼50-60% BNNTs, and ∼40-50% impurities of boron and hexagonal boron nitride. We performed acute in vitro and in vivo studies with commercial grade BNNT-M, dispersed by sonication in vehicle, in comparison to the extensively studied multiwalled carbon nanotube-7 (MWCNT-7). THP-1 wild-type and NLRP3-deficient human monocytic cells were exposed to 0-100 µg/ml and C57BL/6 J male mice were treated with 40 µg of BNN... More

关键词

Boron nitride nanotubes; MWCNT-7; NALP3 inflammasome; inflammation; lysosomal damage; phagocytosis; pyroptosis