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Adiponectin Promotes Human Jaw Bone Marrow Stem Cell Osteogenesis.

J Dent Res. 2016; 
Pu Y, Wu H, Lu S, Hu H, Li D, Wu Y, Tang Z.
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Gene Synthesis The cells were cultured with or without 1 µg/mL APN (Z03072; Genscript, Piscataway, NJ, USA) for 7 d to examine ossification-related gene expression or 21 d for Alizarin Red staining. Get A Quote

摘要

Human jaw bone marrow mesenchymal stem cells (h-JBMMSCs) are multipotent progenitor cells with osteogenic differentiation potential. The relationship between adiponectin (APN) and the metabolism of h-JBMMSCs has not been fully elucidated, and the underlying mechanism remains unclear. The aim of the study was to investigate the effect and mechanism of APN on h-JBMMSC metabolism. h-JBMMSCs were obtained from the primary culture of human jaw bones and treated with or without APN (1 µg/mL). Osteogenesis-related gene expression was evaluated by real-time polymerase chain reaction (PCR), alkaline phosphatase (ALP) activity assay, and enzyme-linked immunosorbent assay (ELISA). To further investigate the signaling pat... More

关键词

APPL1; IBSP; RUNX2; osteocalcin; osteopontin; p38 mitogen-activated protein kinases