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Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice.

Am J Pathol. 2016; 
Jiang S, Wang Q, Huang Z, Song A, Peng Y, Hou S, Guo S, Zhu W, Yan S, Lin Z, Gao X.
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Recombinant Antibody Services Mouse recombinant TNF-a (10 mg/kg) (GenScript, Nanjing, China; Z02918-100) was continuously injected intraperitoneally into Timo mice for 7 days after DJB surgery. Get A Quote

摘要

Duodenum-jejunum gastric bypass (DJB) has been used to treat morbid diabetic patients. However, neither the suitability among patients nor the mechanisms of this surgical treatment is clear. Previously, we reported a new mouse strain named Timo as type 2 diabetes model caused by brain-derived neurotrophic factor (Bdnf) deficiency. In this study, we found that DJB on Timo mice reversed their metabolic abnormalities without altering the expression of Bdnf. Glucose tolerance and insulin sensitivity were improved greatly, along with reduction of fat accumulation in liver and white adipose tissue. The gut flora population was altered by DJB with increased proportion of Firmicutes and decreased Actinobacteria and Pro... More

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