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Long non-coding RNA ANRIL enhances mitochondrial function of hepatocellular carcinoma by regulating the MiR-199a-5p/ARL2 axis.

Environ Toxicol. 2020; 
Li K, Zhao B, Wei D, Cui Y, Qian L, Wang W, Liu G.
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Proteins, Expression, Isolation and Analysis … Then, protein was separated in SDS‐PAGE (SurePAGE™, Cat # M00652, Genscript, Nanjing, China) and transferred onto PVDF membranes, which were incubated with the primary antibodies and followed by incubating with the secondary antibodies … Get A Quote

摘要

Although the roles of long non-coding RNA (lncRNA) ANRIL (Antisense non-coding RNA in the INK4A locus) have been established in various tumors, its roles in mitochondrial metabolic reprogramming of hepatocellular carcinoma (HCC) cells are still unclear. This work aims to explore lncRNA ANRIL roles in regulating the mitochondrial metabolic reprogramming of liver cancer cells. First, we found that lncRAN ANRIL expression was significantly increased in HCC tissues or cells compared with the normal adjacent tissues and normal tissues or cells. Functional experiment showed that overexpression of lncRNA ANRIL promoted mitochondrial function in HCC cells, evident by the increased mitochondrial DNA copy numbers, ATP (A... More

关键词

ANRIL; ARL2; ceRNA; hepatocellular carcinoma; lncRNA; miR-199a-5p