凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and Parkinson's disease

ScienceDirect. 2020; 
Oum KaltoumHassaniaVladimir V.RymaraKhanh Q.NguyenaLiaHuoaJean-FrançoisCloutieraFreda D.MillerbAbbas F.Sadikota
Products/Services Used Details Operation
Recombinant Proteins Santa Cruz, SC-546), total TrkB (1:1000, rabbit; Cell Signaling Technologies, 4603), phosphorylated TrkB (1:1000, rabbit; Epitomics, 2149), and β-actin (1:6000, mouse; GenScript, A00702). Get A Quote

摘要

The cause of midbrain dopaminergic (mDA) neuron loss in sporadic Parkinson's disease (PD) is multifactorial, involving cell autonomous factors, cell-cell interactions, and the effects of environmental toxins. Early loss of neurons in the locus coeruleus (LC), the main source of ascending noradrenergic (NA) projections, is an important feature of PD and other neurodegenerative disorders. We hypothesized that NA afferents provide trophic support for vulnerable mDA neurons. We demonstrate that depriving mDA neurons of NA input increases postnatal apoptosis and decreases cell survival in young adult rodents, with relative sparing of calbindin-positive subpopulations known to be resistant to degeneration in PD. As a... More

关键词