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O-GlcNAc transferase affects the signal transduction of β1 adrenoceptor in adult rat cardiomyocytes by increasing the O-GlcNAcylation of β1 adrenoceptor

Biochem Biophys Res Commun. 2020-05; 
Hong Cao, Ying Hu, Xiaofang Zhu, Na Yao, Jiaona Gu, Yuhang Wang, Weizhong Zhu
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Proteins, Expression, Isolation and Analysis … COVID-19 campus closures … important role in the regulation of cardiac gene transcription, cell cycle and calcium handling, indicating that OGT may be an effective therapeutic target for heart failure [19,20 … A cAMP ELISA kit (L00460) was purchased from Genscript (Nanjing, China … Get A Quote

摘要

O-GlcNAcylation was first found by Torres and Hart in monocytes. It is a dynamic and reversible post-translational modification catalyzed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). O-GlcNAcylation is increased in diabetic cardiomyopathy (DCM) patients and it has been reported that OGT plays an important role in the regulation of cardiac gene transcription, cell cycle and calcium homeostasis. The purpose of this study is to investigate the effects of OGT on signal transduction and function of β1-adrenoceptor (β1AR) in adult rat cardiomyocytes. We found that after overexpressing OGT by adenovirus vector in adult rat cardiomyocytes, cAMP formation and phosphorylation of phospholamban (PLB) at Ser16 (p1... More

关键词

Cardiomyocytes, Diabetic cardiomyopathy, O-GlcNAc transferase, Phospholamban, β1-adrenoceptor