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Increased Notch2/NF-κB Signaling May Mediate the Depression Susceptibility: Evidence from Chronic Social Defeat Stress Mice and WKY Rats

Physiol Behav. 2020; 
Jiangfeng Liao, Guirong Zeng, Wenting Fang, Weibin Huang, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Chen
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Molecular Biology Reagents … Protein concentrations were quantified with a BCA Protein Assay Kit (Beyotime, cat#P0009, China). An equal amount of proteins was heated at 100°C for 10 min and the proteins were separated by 4-12% Bis-Tris SurePAGE TM Gel (GenScript, M00656, China) in a MOPS or … Get A Quote

摘要

The susceptibility to depression has been attributed to the chronic stress and genetic factors but still fails to identify definite biomarkers. The present study aimed to investigate the role of disrupted Notch signaling in the medial prefrontal cortex of the chronic social defeat stress (CSDS) mice and Wistar Kyoto (WKY) rats. RNA-sequencing and quantitative real-time PCR analyses evidenced the involvement of Notch signaling pathway in depression. Western blotting reported an increased level of Notch2 and NF-κB and a decreased level of Hes1 and Bcl2/Bax ratio both in the susceptible mice when compared with the control or resilient ones and in the depression WKY rats when compared with the Wistar or non-depres... More

关键词

Chronic social defeat stress, Depression, NF-κB, Notch2, Wistar Kyoto rat