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Matrine attenuates heterotopic ossification by suppressing TGF-β induced mesenchymal stromal cell migration and osteogenic differentiation

Biomed Pharmacother. 2020; 
Dong Mao, Xiaoyun Pan, Yongjun Rui, Fengfeng Li
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Catalog Antibody … The absorbance was measured at 562 nm, and ImageJ Software (OsteoMetrics, Inc.) was used to quantize ALP activity. 2.8 … Series one: TGF-β (GenScript, z03431-10, NY) was added to the medium at 5 ng/mL, and the samples were collected at 0, 10, 30 and 60 min … Get A Quote

摘要

objective: Heterotopic ossification (HO) is a debilitating disease characterized by extraskeletal bone formation. Active TGF-β recruits mesenchymal stromal cells (MSCs), which contribute to trauma-induced HO. Inhibiting TGF-β induced MSC migration and osteogenic differentiation could be a promising treatment for HO. Matrine is an alkaloid from the genus Sophora that can suppress pancreatic and hepatic fibrosis by regulating TGF-β/Smad signaling. We conducted this study to evaluate the effects of matrine on HO and explore the mechanisms, we carried out this study. methods: Achilles tendon puncture was performed in C57BL/6J male mice to establish the HO model. Following treatment with matrine for 3, 6, 9, and ... More

关键词

Heterotopic ossification, Matrine, Mesenchymal stromal cells, Osteogenic differentiation, TGF-β