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Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE Proteomics

Front Aging Neurosci. 2020; 
Xianfang Rong, Liping Xiang, Yanfen Li, Hongfa Yang, Weijian Chen, Lei Li, Defeng Liang, Xincai Zhou
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Recombinant Antibody Expression … For Cathepsin B activation, IL-6 (10 ng/ml, Genscript, Z03134), IL- 1β(100 pg/ml, Genscript, Z02978), TNF-α (10 ng/ml, Genscript, Z01001) and recombinant Human CRP protein (1 mg/L, Abcam ab171471) were applied to SK-N-SH APPwt cells for 24 h. For TNF-α inhibition … Get A Quote

摘要

Increasing evidence indicates Chronic Periodontitis (CP) is a comorbidity of Alzheimer's disease (AD), which is the most common form of age-related dementia, and for the latter, effective diagnostic and treatment strategies are lacking. Although inflammation is present in both diseases, the exact mechanisms and cross-links between CP and AD are poorly understood; and a direct association between the two has not been reported. This study aimed to identify a direct serum proteins link between AD and CP. Two-dimensional differential in-gel electrophoresis was employed to analyze serum samples from 12 CP patients and 12 age-matched controls. Furthermore, to determine the molecular link between CP and AD, neuroblast... More

关键词

Alzheimer’s disease, Cathepsin B, biomarker, chronic periodontitis, two-dimensional differential in-gel electrophoresis