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Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery

Colloids Surf B Biointerfaces. 2020; 
Xiying Fan, Yunlong Liang, Yuting Cui, Fei Li, Yue Sun, Junqing Yang, Haipeng Song, Zixian Bao, Rui Nian
Products/Services Used Details Operation
Molecular Biology Reagents … 23235, Rockford, USA). The 12 % Mini-Protein TGX™ precast gel was purchased from GenScript (cat. M01212C, Nanjing, China). The PageRuler Prestained Protein Ladder was purchased from Thermo Fisher Scientific (cat. 26616 and 26634, Rockford, USA) … Get A Quote

摘要

Recently, injectable hydrogels have shown great potential in cell therapy and drug delivery. They can easily fill in any irregular-shaped defects and remain in desired positions after implantation using minimally invasive strategies. Here, we developed hydrogels prepared from tilapia skin collagen and chitosan (HCC). The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively. In addition, the stability of HCC was also affected by the concentration of these two components. HCC10 catalyzed by 10 mg mL tilapia skin collagen and 10 m... More

关键词

Chitosan, Collagen, Cumulative release, Hydrogel, Nanobody