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Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease

Neuropathol Appl Neurobiol. 2021-11; 
Sukanya Srinivasan, Jozsef Gal, Adam Bachstetter, Peter T Nelson
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Catalog Antibody … The primary antibodies used are listed in Table 1 & Suppl Table 1. Mouse anti-DDK antibody was from Genscript (Cat # A00187, 1:1000 dilution) and rabbit anti- β-actin antibody from Rockland Immunochemicals (Cat # 18309, 1:5000 dilution) … Get A Quote

摘要

objective: The heterotetrameric assembly protein complex 2 (AP-2) is a central hub for clathrin-dependent endocytosis. The AP-2 α-adaptin subunit has two major isoforms, encoded by two separate genes: AP2A1 and AP2A2. Endocytosis has been implicated in the pathogenesis of neurodegenerative disease, and recent studies linked α-adaptins (gene variants, splicing defects and altered expression) with late-onset Alzheimer's disease (LOAD) risk. Here, we used multiple antibodies to investigate α-adaptin isoforms and their localization in human brains. methods: The specificities of 10 different α-adaptin antibodies were evaluated using immunoblots after human AP2A1 and AP2A2 plasmid transfection in cultured cells. ... More

关键词

CCV, endolysosomal, human genetics, microglia, neuropathology, tau, tauopathy