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Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Virol Sin. 2021-09; 
Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hongwei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei Wang, Yingbin Wang, Tong Cheng, Ningshao Xia
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Monoclonal Antibody Services … Monoclonal antibodies (mAbs) were purified from ascitic fluid by protein A chromatography (L00664, GenScript, Nanjing, China). The concentrations of mAbs were determined using a Bicinchoninic Acid (BCA) Protein Assay Kit (23227, Thermo Fisher). Monoclonal antibodies … Get A Quote

摘要

Coxsackievirus B1 (CVB1) is a leading causative agent of severe infectious diseases in humans and has been reported to be associated with outbreaks of aseptic meningitis, myocarditis, and the development of chronic diseases such as type 1 diabetes mellitus (T1DM). There is no approved vaccine or effective antiviral therapy to treat CBV1 infection. And animal models to assess the effects of antiviral agents and vaccine remain limited. In this study, we established a neonatal mouse model of CVB1 using a clinically isolated strain to characterize the pathological manifestations of virus infection and to promote the development of vaccines and antiviral drugs against CVB1. One-day-old BALB/c mice were susceptible ... More

关键词

Antiviral evaluation, Coxsackievirus B1 (CVB1), Mouse model, Neutralizing antibody