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Comprehensive interactome analysis of the spike protein of swine acute diarrhea syndrome coronavirus

Biosaf Health. 2021-05; 
Qingxing Wang, Yun Luo, Weijuan Shang, Zhengli Shi, Gengfu Xiao, Leike Zhang
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摘要

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered coronavirus that causes severe and acute diarrhea and rapid weight loss in piglets. SADS-CoV was reported to be capable of infecting cell lines derived from diverse species, including bats, mice, hamsters, rats, chickens, pigs, nonhuman primates, and humans, implying its high risk of cross-species infection. However, its receptor is still unknown. In this study, the receptor-binding domain of the SADS-CoV spike (S) protein was purified and then subjected to affinity purification (AP)-coupled mass spectrometry (MS)-based proteomic analysis to identify the interactors of the SADS-CoV S protein. Forty-three host proteins were identified,... More

关键词

PPIB, SADS-CoV, Spike protein, Vimentin, Virus-host interaction