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Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination

Front Immunol. 2022-02; 
Ayman Al Jurdi, Rodrigo B Gassen, Thiago J Borges, Zhabiz Solhjou, Frank E Hullekes, Isadora T Lape, Orhan Efe, Areej Alghamdi, Poojan Patel, John Y Choi, Mostafa T Mohammed, Brigid Bohan, Vikram Pattanayak, Ivy Rosales, Paolo Cravedi, Camille N Kotton, Jamil R Azzi, Leonardo V Riella
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摘要

introduction: Studies have shown reduced antiviral responses in kidney transplant recipients (KTRs) following SARS-CoV-2 mRNA vaccination, but data on post-vaccination alloimmune responses and antiviral responses against the Delta (B.1.617.2) variant are limited. materials and methods: To address this issue, we conducted a prospective, multi-center study of 58 adult KTRs receiving mRNA-BNT162b2 or mRNA-1273 vaccines. We used multiple complementary non-invasive biomarkers for rejection monitoring including serum creatinine, proteinuria, donor-derived cell-free DNA, peripheral blood gene expression profile (PBGEP), urinary mRNA and donor-specific antibodies (DSA). Secondary outcomes included development of anti... More

关键词

COVID-19, SARS-CoV-2, kidney transplant, monitoring, rejection, vaccine