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CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1

Theranostics. 2022-07; 
Yixuan Lu, Yongxin Mu, Ju Chen, Xinyuan Guan, Ling Guo, Chuanyue Wu
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Recombinant Proteins … Mouse tissues and cells (as specified in each experiment) were isolated and homogenized in pre-cold 1× LDS sample buffer (M00676, GenScript) containing the protease and … Get A Quote

摘要

p53 deficiency is a key causal factor for tumor development and progression. p53 acts in this process through, at least in part, cooperation with YAP1 but the underlying molecular mechanism is incompletely understood. In this paper, we show that CLP36, an actinin-binding cytoskeletal protein, links p53 deficiency to up-regulation of YAP1 expression and sarcoma progression. Immunohistochemical staining and Western blotting were used to investigate the effect of p53 deficiency on CLP36 expression in sarcoma tissues and cells. Furthermore, molecular, cellular, and genetic knockout and knockdown approaches were employed to investigate the functions of CLP36 in regulation of sarcoma cell behavior in culture and tum... More

关键词

AIP-4, CLP36, Sarcoma, YAP1, p53