凯发一触即发

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission

Sci Adv. 2021-07; 
Zhenke Yang, Yang Shi, Huiting Cui, Shuzhen Yang, Han Gao, Jing Yuan
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis mouse anti-V5 (Western blot, 1:1000; IFA, 1:500; A01724-100, GenScript) Get A Quote

摘要

Mosquito midgut epithelium traversal is essential for malaria parasite transmission. Phospholipid flippases are eukaryotic type 4 P-type adenosine triphosphatases (P4-ATPases), which, in association with CDC50, translocate phospholipids across the membrane lipid bilayers. In this study, we investigated the function of a putative P4-ATPase, ATP7, from the rodent malaria parasite Disruption of ATP7 blocks the parasite infection of mosquitoes. ATP7 is localized on the ookinete plasma membrane. While ATP7-depleted ookinetes are capable of invading the midgut, they are eliminated within the epithelial cells by a process independent from the mosquito complement-like immunity. ATP7 colocalizes and interacts with the ... More

关键词