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Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1

Mol Plant. 2021-01; 
Seung Jun Park, Suk Won Choi, Gu Min Kim, Christian Møller, Hyun-Sook Pai, Seong Wook Yang
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Catalog Antibody the supernatant was incubated with α-Myc antibody (cat. no. A00704; GenScript, Piscataway, NJ) for 3 h at 4°C Get A Quote

摘要

The precise regulation of microRNA (miRNA) biogenesis is crucial for plant development, which requires core microprocessors and many fine tuners to coordinate their miRNA processing activity/specificity in fluctuating cellular environments. During de-etiolation, light triggers a dramatic accumulation of core microprocessors and primary miRNAs (pri-miRNAs) but decreases pri-miRNA processing activity, resulting in relatively constant miRNA levels. The mechanisms underlying these seemingly contradictory regulatory changes remain unclear. In this study, we identified forkhead-associated domain 2 (FHA2) as a light-stabilized suppressor of miRNA biogenesis. We found that FHA2 deficiency increased the level of mature ... More

关键词

Suppressor of the microprocessor, miRNA biogenesis, miRNA-biogenetic inconsistency