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Ascorbic acid suppresses endotoxemia and NF-κB signalling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach.

Toxicol Appl Pharmacol.. 2013-11; 
Abhilash PA, Harikrishnan R, Indira M. Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-695 581, Kerala, India.
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摘要

Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signalling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-κB activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4g/kg b.wt for 90days. After 90days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250mg/kg b.wt) and AA (250mg/kg b.wt) supplemented groups and maintained for 30days. The SIBO, intestinal permeab... More

关键词

alcohol; ascorbic acid; guinea pigs; hepatocytes; liver toxicity