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Transcription factor EB (TFEB) is selectively reduced in the nuclear fractions of Alzheimer's and Amyotrophic lateral sclerosis brains.

Neurosci J.. 2016-06; 
H Wang, R Wang, S Xu, MK Lakshmana.
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... Polyclonal lamin A+C antibody (cat # A01455) was purchased from Genscript (Piscataway, NJ, USA). Mouse monoclonal antibody against alpha tubulin (cat # A01410) was purchased from Genscript USA Inc. (Piscataway, NJ, USA). ...

摘要

Multiple studies suggest that autophagy is strongly dysregulated in Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), as evidenced by accumulation of numerous autophagosomes, lysosomes with discontinuous membranes, and aggregated proteins in the patients' brains. Transcription factor EB (TFEB) was recently discovered to be a master regulator of lysosome biogenesis and autophagy. To examine whether aberrant autophagy in AD and ALS is due to alterations in TFEB expression, we systematically quantified the levels of TFEB in these brains by immunoblotting. Interestingly, cytoplasmic fractions of AD brains showed increased levels of normalized (to tubulin) TFEB only at Braak stage IV (61%, p < 0.01).... More

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