凯发一触即发

随机肽库(Random Library)

是序列优化必不可少的工具。随机肽库生成的特有序列有提升多肽活性的潜力。该类肽库是利用"散弹枪"法,对选取的位点利用20种天然氨基酸进行随机自发取代而得到的。

应用领域

多肽序列优化

鉴定靶点

多肽药物

Overlapping Peptide
Alanine Scanning
Truncation Library
Positional Scanning
Random Library
Scrambled Library
T Cell Truncated Library
 

参考文献

    Lam KS. Application of combinatorial library methods in cancer research and drug discovery. Anticancer Drug Des. Apr 1997: 12(3): 145-67.

    Marasco D, Perretta G, Sabatella M, and Ruvo M. Past and future perspectives of synthetic peptide libraries. Curr. Protein Pept. Sci. Oct 2008; 9(5): 447-67.

    Menendez A, and Scott JK. The nature of target-unrelated peptides recovered in the screening of phage-displayed random peptide libraries with antibodies. Anal. Biochem. Jan 2005 15; 336(2): 145-57.

    Irving MB, Pan O, and Scott JK. Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics. Curr. Opin. Chem. Biol. Jun 2001; 5(3): 314-24.

    Yang M, Wu Z, and Fields S. Protein-peptide interactions analyzed with the yeast two-hybrid system. Nucleic Acids Res. Apr 1995; 11; 23(7): 1152-6.

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